“The season just got better for AlyssA.
We’re excited to have her on board, and we’re so excited to be a part of Grey’s Anatomical,” showrunner Dan Goor said in a statement.
“We hope that Alyss will be a terrific addition to our growing cast and crew.”
“Grey’s” premiere was the series’ first without Alyssha, a character that had appeared in previous seasons but never had an on-screen relationship.
The actress, who will play an older woman with dementia, is set to play an even older woman in Season 6, while the younger woman will be the new showrunner of the series, which returns to ABC on Sept. 22.
Milano is set for a major role on the show in the season premiere.